At Nitric Oxide Services, we specialize in comprehensive validation of medical devices, supplements, nitric oxide precursors and donors, especially within the realm of applications in health and medicine including exercise science. We have worked successfully to advance client projects in the areas of implant protection, hand sanitization, as well as devices that produce and monitor nitric oxide (NO).

We are adept in consulting services related to FDA 510(k) clearances, New Drug Applications (NDAs), and the strategic planning and execution of nonclinical trials.

We provide patentability searches, freedom to operate search, patent validity search, patent landscape analysis as well as trademark search for nitric oxide and nitric oxide related technologies. 

Leveraging our extensive experience, we are committed to meeting the unique needs of each project with an unwavering attention to detail.

Whether it’s navigating regulatory complexities or designing an effective trial, our team is equipped to provide timely and efficient solutions, ensuring your project's success in the dynamic field of nitric oxide applications.

​​​We are nitric oxide capable™


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Nitric Oxide Services, LLC is thrilled to announce a significant milestone achieved in collaboration with Plasma Futures. Our joint efforts have culminated in the publication of a groundbreaking pre-print:

Safety and efficacy of the Plasma Directed Electron Beam (PDEB™) - implications for enhanced wound healing treatment in military operational medicine and beyond
Joseph A. Bauer, Adrianne R. Blocklin, Annette M. Sysel, Thomas J. Sheperak
medRxiv 2024.02.21.24302399; doi:


Dr. Bauer, an expert in nitric oxide, (President of Nitric Oxide Services, LLC) presented on behalf of Plasma Futures’ nitric oxide generating platform “Nonthermal Plasma Directed Electron Beam (NT-PDEB™) as a Treatment Modality for Wound Healing in Combat Casualty Care and Military Operational Medicine; MHSRS-23-10578” at the 2023 Military Health Science Research Symposium (MHSRS) in the Breakout Session “Tissue Wound Management for Prolonged Care Environments” on Tuesday August 15th at 8:30 am.



Dr. Bauer  discusses Cancer Drug Discovery and Development to students and faculty of the Center for Molecular Biology and Biotechnology (CMBB) Fall 2022 Virtual Lecture Series on January 24, 2022 at Florida Atlantic University. 


Sysel AM, Dunphy MJ, Bauer JA. Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study. J Antibiotics . 2021 Apr;74(4):260-265. doi: 10.1038/s41429-020-00397-9. Epub 2020 Dec 28. PMID: 33361779; PMCID: PMC7767638.


Bauer JA, Lupica JA, Didonato JA, Lindner DJ. Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance. Anticancer Res. 2020 Dec;40(12):6751-6763. doi: 10.21873/anticanres.14698. Epub 2020 Dec 7. PMID: 33288568.


Sysel AM, Dunphy MJ, Lindner DJ, DiDonato JA, Lupica JA, Bauer JA. Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability. J Biol Chem. 2020 Oct 23;295(43):14789. doi: 10.1074/jbc.L120.016007. PMID: 33097647; PMCID: PMC7586211.


Dr. Bauer receives Long Service Editorial Board Member Award from  PLoS ONE. February 28, 2023.


Nitric Oxide Services, LLC

Our Clients

Nitric Oxide Services, LLC (NOS), is a consulting and research firm specializing in the investigation, evaluation, and application of nitric oxide and related substances in various health and medical contexts. We have a strong reputation in the field, owing to our experienced team of researchers, clinicians, and consultants who have a comprehensive understanding of the complex biochemistry of nitric oxide and its potential benefits in the human body.

Our lab has access to state of the art analytical equipment, tissue culture, and chemical reactors.