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Welcome to Nitric Oxide Services, LLC (NOS) — Your CLIA-Certified Partner in Nitric Oxide Science

​​​​Nitric Oxide Services, LLC — Your CLIA-Certified Partner for Nitric Oxide and Clinical Validation Services

At Nitric Oxide Services, LLC, we specialize in the comprehensive validation of medical devices, dietary supplements, nitric oxide precursors and donors, with a focus on applications in health, medicine, and exercise science. Our team has successfully advanced client projects across a wide range of applications, including implant protection, hand sanitization, and devices that produce or monitor nitric oxide (NO).

We are a CLIA-certified laboratory (CLIA# 36D2321191), enhancing our ability to provide high-quality, regulatory-compliant NOx (nitrate, nitrite) biomarker testing and other laboratory services to support your clinical trial and product validation needs.

In addition to laboratory testing, we offer expert consulting services in regulatory pathways including:

  • FDA 510(k) clearances
  • New Drug Applications (NDAs)
  • Strategic planning and execution of nonclinical trials


Our intellectual property services include:

  • Patentability searches
  • Freedom to operate analyses
  • Patent validity searches
  • Patent landscape reviews
  • Trademark searches


With decades of combined experience, our team is committed to providing customized solutions tailored to your project’s unique needs. Whether you require regulatory guidance, laboratory testing, or assistance navigating the complexities of clinical development, Nitric Oxide Services, LLC is your trusted partner.

We are ready to help you bring your innovations to market — accurately, efficiently, and in full regulatory compliance.

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IN THE NEWS

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MARCH 2025 

PUBLICATION ALERT!


Sysel AM, Bauer JA. Evaluation of the Binding Affinity of Nitrosylcobalamin to Intrinsic Factor as a Predictive Model for Cobalamin Binding Protein Interactions: A Comparative Study with Hydroxocobalamin 2025 Frontiers in Bioscience Elite.



Dr. Bauer  discusses Cancer Drug Discovery and Development to students and faculty of the Center for Molecular Biology and Biotechnology (CMBB) Fall 2022 Virtual Lecture Series on January 24, 2022 at Florida Atlantic University. 




​Sysel AM, Dunphy MJ, Bauer JA. Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study. J Antibiotics . 2021 Apr;74(4):260-265. doi: 10.1038/s41429-020-00397-9. Epub 2020 Dec 28. PMID: 33361779; PMCID: PMC7767638.




Bauer JA, Lupica JA, Didonato JA, Lindner DJ. Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance. Anticancer Res. 2020 Dec;40(12):6751-6763. doi: 10.21873/anticanres.14698. Epub 2020 Dec 7. PMID: 33288568.



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​Sysel AM, Dunphy MJ, Lindner DJ, DiDonato JA, Lupica JA, Bauer JA. Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability. J Biol Chem. 2020 Oct 23;295(43):14789. doi: 10.1074/jbc.L120.016007. PMID: 33097647; PMCID: PMC7586211.


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Our Clients

​​Nitric Oxide Services, LLC (NOS) is a premier consulting and research organization dedicated to advancing the science and application of nitric oxide and related biochemical pathways in health, medicine, and exercise science. Our mission is to help clients optimize physiological function, improve clinical outcomes, and drive innovation through nitric oxide-based solutions.

As a CLIA-certified laboratory (CLIA# 36D2321191), we meet the highest federal standards for laboratory quality and compliance. This certification enhances our ability to deliver validated, high-precision nitric oxide (NOx: nitrate and nitrite) biomarker testing, supporting both clinical trials and product development with data you can trust.

Backed by a multidisciplinary team of seasoned researchers, clinicians, and consultants with decades of combined experience, NOS operates at the forefront of nitric oxide science and translational research.

Our laboratory is equipped with:

  • State-of-the-art analytical instrumentation
  • Tissue culture facilities
  • Specialized chemical reactors
  • CLIA-compliant biomarker testing services


In addition, we have privileged access to the Comparative Medicine Unit (CMU) — a 41,000-square-foot, fully accredited preclinical research facility. The CMU maintains full compliance with USDA regulations and holds an Animal Welfare Assurance from the Office of Laboratory Animal Welfare (OLAW), supporting advanced preclinical studies.

At NOS, we integrate cutting-edge research, regulatory expertise, and clinical trial support to advance the boundaries of nitric oxide science. Whether you are developing medical devices, supplements, or therapeutic interventions, we are here to accelerate your innovation with trusted data and proven results.